Update on imaging-based diagnosis of acute renal allograft rejection

American Journal of Nuclear Medicine and Molecular Imaging

Uta Schnöckel¹  Richard Köhnke²  Dominik Kentrup³  Katharina Schütte-Nütgen⁴  Michael Schäfers⁵  Verena Hoerr⁶ 

[1] Department of Clinical Radiology, University Hospital of Muenster, 48149 Muenster, Germany;Department of Medicine, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany;Department of Medicine, Division of Nephrology, The University of Alabama at Birmingham (UAB), 35294 Birmingham Alabama, US;Department of Nuclear Medicine, University Hospital of Muenster, 48149 Muenster, Germany;European Institute for Molecular Imaging, University of Muenster, 48140 Muenster, Germany;Institute of Medical Microbiology, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany

关键词: Acute allograft rejection;    imaging;    noninvasive;    ultrasound;    PET;    SPECT;    MRI;    kidney transplantation;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Kidney transplantation is the preferred treatment for patients with end-stage renal disease. Despite effective immunosuppressants, acute allograft rejections pose a major threat to graft survival. In early stages, acute rejections are still potentially reversible, and early detection is crucial to initiate the necessary treatment options and to prevent further graft dysfunction or even loss of the complete graft. Currently, invasive core needle biopsy is the reference standard to diagnose acute rejection. However, biopsies carry the risk of graft injuries and cannot be immediately performed on patients receiving anticoagulation drugs. Therefore, non-invasive assessment of the whole organ for specific and rapid detection of acute allograft rejection is desirable. We herein provide a review summarizing current imaging-based approaches for non-invasive diagnosis of acute renal allograft rejection.

【 授权许可】

CC BY-NC