Effect of Etoposide Treatment on ERG Transfected H358 Cell Line

Proceedings

Sergi, Barış¹  Alkhatib, Sara²  Kandemiş, Emine³  Bulut, Gülay⁴ 

[1] Authors to whom correspondence should be addressed.;Bioengineering Program, Graduate School of Natural and Applied Sciences, Bahçeşehir University, 34353 Istanbul, Turkey;Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Bahçeşehir University, 34353 Istanbul, Turkey;Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018.

关键词: lung cancer;    ERG;    ETS;    EMT;    etoposide;   

DOI  :  10.3390/proceedings2251589

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Lung cancer is listed as the most fatal type of cancer around the world. ERG, a transcription factor, is an ETS family member protein. It is involved in Epithelial Mesenchymal Transition (EMT), metastasis and DNA repair defects. Etoposide is a chemotherapeutic agent used in treatment of a variety of different cancer types, including lung cancer. Moreover, Etoposide has been tested alone and in combination with other drugs in order to inhibit DNA synthesis and exhibit antitumor activity. The purpose of this study is to examine the effect of Etoposide treatment on ERG transfected non-small cell lung cancer (NSCLC) cell line, H358.

【 授权许可】

CC BY