Whether Lack of Measurement of Erythrocyte Cholinesterase or Acetyl Cholinesterase Activity Providing us Misleading Information in Organophosphorus Exposure?

Indian journal of clinical biochemistry: IJCB

Sheemona Chowdhary¹ 

[1]Postgraduate Institute of Medical Education and Research

DOI  :  10.1007/s12291-018-0737-y

学科分类：过敏症与临床免疫学

来源: Springer

【 摘 要 】

It is an established fact that erythrocytes contain acetylcholinesterase and it is considered as gold standard biomarker for organophosphorous poisoning [1]. Plasma contains high concentration of Butyrylcholinesterase that cleaves acetylthiocholine significantly [2]. However, many researchers use acetylthiocholine in plasma or serum and claim for the estimation of acetylcholinesterase activity. Some authors address the specificity issue by performing the experiments in presence and absence of a specific butyrylcholinesterase inhibitor and others publish results even without taking any care to report for specific acetylcholinesterase activity [3, 4]. It appears that due to misconception of facts plasma cholinesterase activity and plasma acetylcholinesterase activity is used synonimous by authors even at recent times. We feel that such misconception should be corrected because of the following reasons.

【 授权许可】

CC BY