Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

Jundishapur Journal of Microbiology

Azam Bakhshandeh¹  Maryam Zangi² 

[1] Aryatinagene Biopharmaceutical Company, Gorgan, Iran;Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran

关键词: Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province;    Northern Iran;    Hepatitis B Virus (HBV);    Hepatocellular Carcinoma (HCC);    Interleukin-13;    Polymerase Chain Reaction (PCR);    Polymorphism;   

DOI  :  10.5812/jjm.68270

学科分类：微生物学和免疫学

来源: Jundishapur Journal of Microbiology

【 摘 要 】

The most common primary cause of liver cancer is hepatocellular carcinoma (HCC). Cytokines as mediators have significant roles in immune and inflammatory responses. Interleukin-13 (IL-13) is a potent pleiotropic cytokine.The aim of this study was to evaluate the association of IL-13/+110 gene polymorphism in patients with chronic hepatitis B virus (HBV), one of the most important factors that lead to the development of HCC.DNA was extracted from peripheral blood cells of all 585 participants including 302 unrelated Hepatitis B surface antigen (HBS-Ag) positives and 283 healthy matched groups. The IL-13 gene polymorphism (+ 110 A or G) was genotyped by SSP-PCR method and then genotype frequencies were checked by using the Pearson’s chi-square test and/or Fisher exact test.The frequencies of A/G genotype (CI = 1.18 - 2.34, OR = 1.66, P = 0.004) and A/A genotype (CI = 0.95 - 3.53, OR = 1.84, P = 0.071) were higher in the patients. Also, the frequency of A allele was remarkably higher in the HBV patients than control group (CI = 1.09 - 1.79, OR = 1.84, P = 0.071).High frequency of A allele in patients rather than control group suggested that A allele probably plays a role in augmenting susceptibility to HBV infection risk and high frequency of G allele in controls suggested this allele has a protective role in this disease.

【 授权许可】

CC BY-NC