Pathogenesis of oral type I feline infectious peritonitis virus (FIPV) infection: Antibody-dependent enhancement infection of cats with type I FIPV via the oral route

The Journal of Veterinary Medical Science

Shinji YAMADA¹  Tomomi TAKANO² 

[1] Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan;School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan

关键词: antibody-dependent enhancement;    feline coronavirus;    feline infectious peritonitis;    oral infection;   

DOI  :  10.1292/jvms.18-0702

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Feline infectious peritonitis virus (FIPV) causes a severe, immune-mediated disease called FIP in domestic and wild cats. It is unclear whether FIP transmits from cat to cat through the oral route of FIPV infection, and the reason for this includes that FIP is caused by oral inoculation with some FIPV strains (e.g., type II FIPV WSU 79-1146), but is not caused by other FIPV (e.g., type I FIPV KU-2 strain: FIPV-I KU-2). In this study, when cats passively immunized with anti-FIPV-I KU-2 antibodies were orally inoculated with FIPV-I KU-2, FIP was caused at a 50% probability, i.e., FIPV not causing FIP through oral infection caused FIP by inducing antibody-dependent enhancement. Many strains of type I FIPV do not cause FIP by inoculation through the oral route in cats. Based on the findings of this study, type I FIPV which orally infected cats may cause FIP depending on the condition.

【 授权许可】

Unknown