Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

Sociedade Brasileira de Medicina Tropical. Revista

Santos, Ana Paula de Azevedo¹  Oliveira, Flávio Augusto de Souza²  Passarini, Guilherme Matos³  Medeiros, Daniel Sol Sol de⁴ 

[1] Centro Universitário São Lucas, Porto Velho, Brasil;Faculdade de Educação e Cultura de Vilhena, Vilhena, Brasil;Fundação Oswaldo Cruz, Porto Velho, Brazil;Fundação Universidade Federal de Rondônia, Porto Velho, Brazil

关键词: Malaria;    Leishmaniasis;    Piper;    Bioactivity.;   

DOI  :  10.1590/0037-8682-0309-2017

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTIONThis study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis.METHODSThe effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured.RESULTSThree compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity.CONCLUSIONSThe tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.

【 授权许可】

CC BY