Development of Periungual Pyogenic Granuloma with Associated Paronychia Following Isotretinoin Therapy: A Case Report and a Review of the Literature

The Journal of Clinical and Aesthetic Dermatology

Leila Ettefagh¹  Conrad Benedetto²  Dave Crasto³ 

[1] .;Drs. Benedetto, Ettefagh, and Nami are with the Western University of Health Sciences in Pomona, California;Mr. Crasto is with William Carey University College of Osteopathic Medicine in Hattiesburg, Mississippi

关键词: Isotretinoin;    pyogenic granuloma;    drug-induced;    periungual;    paronychia;   

DOI  :  

学科分类：医学（综合）

来源: Matrix Medical Communications, LLC

【 摘 要 】

The development of periungual pyogenic granulomas while taking the oral acne drug isotretinoin is a known yet uncommon and potentially severe side effect of the oral vitamin A derivative. Previous reports have detailed the development of pyogenic granulomas most commonly arising at sites of previous acne lesions as well as both subungual and periungual locations, with associated paronychia, bleeding, and discomfort. This is thought to arise as a result of the nail bed’s fragility and propensity toward spicule formation brought on by the proliferative action of isotretinoin. Here, we report a case of periungual pyogenic granuloma with associated paronychia in a patient taking oral isotretinoin. A review of the pathogenesis and available treatment modalities based on the current literature is provided.

【 授权许可】

Unknown