A Report on Finding a New Peptide Aldehyde from Cyanobacterium Nostoc sp. Bahar M by LC-MS and Marfey’s Analysis

Iranian Journal of Biotechnology

Nowruzi, Bahareh¹  Wahlsten, Matti² 

[1] Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran;Division of Microbiology, Department of Food and Environmental Sciences, University of Helsinki, Finland

关键词: bioactive compounds;    Cyanobacteria;    Nostoc;   

DOI  :  10.21859/ijb.1853

学科分类：生物技术

来源: National Institute for Genetic Engineering and Biotechnology

【 摘 要 】

Background: Cyanobacteria have a worldwide distribution in the terrestrial habitats, occurring predominantly on the surface of the soils, stones, rocks, and trees, practically in moist, neutral or alkaline aeries. The unique natural and bioactive compounds from cyanobacteria with various biological activities and an extensive range of chemical classes have a significant capability for expansion of the pharmaceuticals and other biomedical purposes. Objectives: Regardless of the progresses in our knowledge on cyanobacteria, however, cyanobacteria are still viewed as an unexplored source of potential drugs. In this study presence of bioactive compounds among the cyanobacteria culture collection of Iran, where a wide variety of strains can be found, was investigated. Material and Methods: We explored one Nostoc strain isolated from rice fields in Golestan province of northern Iran for searching for novel products. The chemical construction of the new bioactive compound was clarified by application of liquid chromatography-mass spectrometer (LC-MS) and Marfey’s analysis of the degradation products. Results: We found a novel peptide aldehyde compound from a hydrophilic extract of the Nostoc sp. Bahar_M, which is composed of the three subunits, 2-hydroxy-4-(4-hydroxyphenyl) butanoic acid (Hhpba), L-Ile, and L-argininal. According to the structural information, we predicted that the novel peptide-aldehyde compound probably to be trypsin inhibitors. Conclusions: Results demonstrated that terrestrial cyanobacteria are a promissing resource of bioactive natural products.

【 授权许可】

Unknown