Phosphodiesterase Type 5 Inhibitors and sudden sensorineural hearing loss

Revista Brasileira de Otorrinolaringologia

Barreto, Monique Antunes de Souza Chelminski¹  Bahmad Jr, Fayez² 

[1] Fundação Hospitalar do Distrito Federal;UnB

关键词: phosphodiesterase type 5 inhibitors and sudden deafness and its correlates in the English language.;   

DOI  :  10.5935/1808-8694.20130133

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Phosphodiesterase type 5 Inhibitors, such as sildenafil, vardenafil and tadalafil have been increasingly used today and some of the users have developed sudden sensorineural hearing loss.OBJECTIVE:To present two patients with sudden deafness developed after an occasional use of the drug and review studies on the use of phosphodiesterase type 5 inhibitors and sudden hearing loss.METHOD:Analytical study of two cases and review of the subject matter in the Pubmed/Medline and Bireme databases using the keywords: phosphodiesterase type 5 inhibitors and sudden deafness and its correlates in the English language.RESULTS:The patients analyzed are young without additional disorders, using phosphodiesterase type 5 inhibitors, and after combination treatment for sudden hearing loss only one had hearing improvement. We found nine scientific studies and reviewed preclinical studies, clinical trials, prospective and cross-sectional investigations.CONCLUSION:Increased occurrence in clinical practice and scientific reports in the literature suggest that the phosphodiesterase type 5 inhibitors are considered a risk factor for sudden deafness. Further studies with larger samples and control groups are needed for better assessing this association.

【 授权许可】

CC BY