Composite of AuNPs@SiO$_2$NPs@[(NIPAM)-$b$-(Ala)] and its activity on leukemia cells

Bulletin of Materials Science

D S D SUMAN JOSHI^3¹  MOHAN LAKAVATHU^2²  CHANDER AMGOTH^1³ 

[1] Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India^3;School of Chemistry, University of Hyderabad, Hyderabad 500046, India^2;School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046, India^1

关键词: Composite;    gold nanoparticles;    silica nanoparticles;    cell inhibition;    [(NIPAM)-$b$-(Alanine)].;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

Synthesis and characterization of thermo-sensitive block copolymer of N-isopropyl acryl amide-$b$-Alanine [(NIPAM)-$b$-(Alanine)] thin film and its doping with (AuNPs)–(SiO$_2$NPs), (gold and silica nanoparticles) were reported. Further, composite effect on K562 (leukemia) cells was examined based on in vitro cell-based studies. The synthesis of SiO$_2$NPs was followed through facile Stober’s sol–gel synthesis methods. The individual morphology of [(NIPAM)-$b$-(Alanine)] thin film, AuNPs and SiO$_2$NPs including [(NIPAM)-$b$-(Alanine)]@(Au)-(SiO$_2$NPs) composite was confirmedby using TEM instrumentation. [(NIPAM)-$b$-(Alanine)] thin film was embedded with gold and silica nanoparticles followed by the sonication. The average size of AuNPs is 16 nm and for SiO$_2$NPs, it is $\sim$368 nm (in diameter). Synthesized composite [(NIPAM)-$b$-(Alanine)]@(Au)@(SiO$_2$NPs) is biocompatible for mankind use. However, composite used to examine theinhibitory activity on K562 cells and it shows $\sim$78% inhibition, which is significant value for 24 h treatment under humidified atmospheric conditions.

【 授权许可】

CC BY