Crystal structure of tebipenem pivoxil

Acta Crystallographica Section E: Crystallographic Communications

Tang, C.¹  Cai, L.² 

[1] China State Institute of Pharmaceutical Industry, 285 Gebaini Rd, Shanghai 201203, People's Republic of China;University of South Carolina Lancaster, 476 Hubbard Drive, Lancaster, SC 29720, USA

关键词: CRYSTAL STRUCTURE;    CARBAPENEM;    ANTIBIOTICS;    TEBIPENEM;    PRODRUG;    HYDROGEN BONDING;   

DOI  :  10.1107/S2056989018010770

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

The mol­ecular structure of the first orally active carbapenem anti­bacterial agent, tebipenem pivoxil (systematic name: (2,2-di­methyl­propano­yloxy)methyl (4R,5S,6S)-3-{[1-(4,5-di­hydro-1,3-thia­zol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1R)-1-hy­droxy­eth­yl]-4-methyl-7-oxo-1-aza­bicyclo­[3.2.0]hept-2-ene-2-carboxyl­ate), C22H31N3O6S2, has been determined and the configurations of the four chiral centers validated. The title compound crystallizes in the triclinic space group P1 with one mol­ecule in the unit cell. Three out of the four rings adopt planar conformations while the thia­zolinyl ring adopts an enveloped conformation. In the crystal, O—H⋯N hydrogen bonds link the mol­ecules into chains along [1\overline{1}0].

【 授权许可】

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