The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD)

Revista Brasileira de Otorrinolaringologia

Spies, Jonas Willian¹ 

[1] Universidade de São Paulo, Ribeirão Preto, Brazil

关键词: Desensitization immunological;    Aspirin;    Sinusitis;    Nasal polyps.;   

DOI  :  10.1016/j.bjorl.2015.04.010

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

INTRODUCTION:Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options.OBJECTIVE:To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD.METHODS:Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized.RESULTS:Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up.CONCLUSION:Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response.

【 授权许可】

CC BY