NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes

Radiology and Oncology

Janez Simenc^1¹ 

[1] University of Ljubljana, Faculty of Medicine, Department of Pharmacology and Experimental Toxicology, Ljubljana, Slovenia^1

关键词: astrocytes;    VAS2870;    mitochondrial potential;    ATP;    reactive oxygen species;    cell death;   

DOI  :  10.2478/raon-2019-0002

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundAstrocytes maintain central nerve system homeostasis and are relatively resistant to cell death. Dysfunction of cell death mechanisms may underlie glioblastoma genesis and resistance to cancer therapy; therefore more detailed understanding of astrocytic death modalities is needed in order to design effective therapy. The purpose of this study was to determine the effect of VAS2870, a pan-NADPH oxidase inhibitor, on staurosporine-induced cell death in astrocytes.

【 授权许可】

Unknown