Inhibitor of DNA binding proteins: implications in human cancer progression and metastasis

American Journal of Translational Research

Yong Chen¹  Ruolin Wu³  Jing Ke⁴  Mohammed L Abba⁵ 

[1] Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, University of Heidelberg, Mannheim 68167, Germany;Department of Hematology and Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;Department of Hepatopancreatobiliary Surgery and Organ Transplantation Center, Department of General Surgery, First Affiliated Hospital of Anhui Medical University, 218 Jixi Avenue, Hefei 230022, Anhui, China;Department of Liver Disease, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Medical Oncology, Subei Peoples Hospital, Yangzhou, Jiangsu 225000, China

关键词: Inhibitor of DNA binding protein;    cancer progression;    metastasis;    cancer stem cells;    cancer therapy;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Inhibitor of DNA binding (ID) proteins are a class of helix-loop-helix (HLH) transcription regulatory factors that act as dominant-negative antagonists of other basic HLH proteins through the formation of non-functional heterodimers. These proteins have been shown to play critical roles in a wide range of tumor-associated processes, including cell differentiation, cell cycle progression, migration and invasion, epithelial-mesenchymal transition, angiogenesis, stemness, chemoresistance, tumorigenesis, and metastasis. The aberrant expression of ID proteins has not only been detected in many types of human cancers, but is also associated with advanced tumor stages and poor clinical outcome. In this review, we provide an overview of the key biological functions of ID proteins including affiliated signaling pathways. We also describe the regulation of ID proteins in cancer progression and metastasis, and elaborate on expression profiles in cancer and the implications for prognosis. Lastly, we outline strategies for the therapeutic targeting of ID proteins as a promising and effective approach for anticancer therapy.

【 授权许可】

CC BY-NC