Antigenic heterogeneity among phylogenetic clusters of influenza D viruses

The Journal of Veterinary Medical Science

Hiroho ISHIDA¹  Tomoha ODAGIRI² 

[1] Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 3145 Ago, Kasama, Ibaraki 319-0206, Japan;Laboratory of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: antigenicity;    cattle;    hemagglutinin-esterase-fusion protein;    influenza D virus;    serology;   

DOI  :  10.1292/jvms.18-0157

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutinin-esterase-fusion protein of flu D viruses.

【 授权许可】

Unknown