The Journal of Veterinary Medical Science | |
Antigenic heterogeneity among phylogenetic clusters of influenza D viruses | |
Hiroho ISHIDA1  Tomoha ODAGIRI2  | |
[1] Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 3145 Ago, Kasama, Ibaraki 319-0206, Japan;Laboratory of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan | |
关键词: antigenicity; cattle; hemagglutinin-esterase-fusion protein; influenza D virus; serology; | |
DOI : 10.1292/jvms.18-0157 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutinin-esterase-fusion protein of flu D viruses.
【 授权许可】
Unknown
【 预 览 】
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RO201910257338362ZK.pdf | 839KB | download |