BMC Microbiology | |
Genetic polymorphisms identify in species/biovars of Brucella isolated in China between 1953 and 2013 by MLST | |
Xi Liu1  Dong-dong Di2  Pei Xiao3  Dong-ri Piao4  | |
[1] Laboratory of Zoonoses, China Animal Health and Epidemiology Center, MOA, Qingdao, China;National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China;Qinghai Institute for Endemic Disease Prevention and Control, Xining, China;State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China | |
关键词: Brucella; Molecular epidemiology; Genotype; MLST; | |
DOI : 10.1186/s12866-018-1149-0 | |
学科分类:微生物学和免疫学 | |
来源: BioMed Central | |
【 摘 要 】
Brucellosis incidence in China is divided into three stages: high incidence (1950s–1960s), decline (1970s–1980s), and re-emergence (1990s–2010s). At the re-emergence stage, Brucellosis incidence grew exponentially and spread to all 32 provinces. We describe the magnitude and the etiological distribution changes in mainland China by genotyping data and emphasize its recent reemergence. We also provide the genetic diversity and molecular epidemiological characteristics of Brucella. From a total of 206 Brucella isolates, 19 MLST genotypes (STs) were identified and 13 new STs(ST71–83)were found. MLST grouped the population into three clusters. B. melitensis, B. abortus and B. suis were grouped into cluster 1, 2 and 3 respectively. The predominant genotype in the first cluster by MLST, remained unchanged during the three stages. However, the proportion of genotypes in the three stages had changed. More isolates were clustered in ST8 at the re-emergence stage. STs71–74, which were not found in the two former stages, appeared at the re-emergence stage. The changing molecular epidemiology of brucellosis improve our understanding of apparent geographic expansion from the historically affected north of China to southern provinces in recent reemergence.
【 授权许可】
CC BY
【 预 览 】
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RO201910257337882ZK.pdf | 1146KB | download |