Radiation therapy and immunotherapy—a potential combination in cancer treatment

Current oncology

A. Livoff¹  R. Batash²  P. Schaffer³  R. Debbi⁴  N. Asna⁵ 

[1] Ben Gurion University of the Negev;Ben Gurion University of the Negev;University of Oradea;Bad Trissl;Barzilai Medical Center

关键词: Radiation therapy;    abscopal effect;    immunotherapy;    checkpoint blockade;    combination therapy;    PD-L1;   

DOI  :  10.3747/co.25.4002

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

BackgroundRadiation therapy ( rt ) is a longstanding treatment modality for cancer. In addition, immune checkpoint blockade has been a significant development in the field of immunotherapy, modifying key immunosuppressive pathways of cancer cells.MethodsThe aim of the present work was to review current concepts of  rt  and immunotherapy synergism, the abscopal effect, and the molecular effects of  rt  in the tumour microenvironment, its influence on immune stimulation, and potential clinical outcomes that might evolve from ongoing studies. We also discuss potential predictors of clinical response.ResultsUp-to-date literature concerning the mechanisms, interactions, and latest knowledge about  rt  and immunotherapy was reviewed and summarized, and is presented here.ConclusionsThe possibility of using hyperfractionated  rt  to combine an abscopal effect with the enhanced effect of immune treatment using checkpoint blockade is a very promising method for future tumour treatments.

【 授权许可】

Unknown