The role of gut microbiota in non-alcoholic fatty liver disease: pathways of mechanisms

Bioscience of Microbiota, Food and Health

Chyntia Olivia Maurine JASIRWAN¹  Andri Sanityosos SULAIMAN¹  Irsan HASAN¹  Cosmas Rinaldi Adithya LESMANA¹  Rino Alvani GANI¹ 

[1] Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Pangeran Diponegoro Road No. 71st, Central Jakarta 10430, Indonesia

关键词: gut microbiota;    dysbiosis;    NAFLD;    inflammatory pathway;    metabolic pathway;   

DOI  :  10.12938/bmfh.18-032

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence increases with increasing rates of obesity, insulin resistance, and diabetes mellitus. The pathogenesis of NAFLD involves many factors, including the gastrointestinal microbiota. However, there is still debate about the impact of gut dysbiosis in the NAFLD disease progression. Therefore, this paper aims to review the relationship between gut microbiota and other risk factors for NAFLD and how gut dysbiosis plays a role in the pathogenesis of NAFLD. Hopefully, this paper can make an appropriate contribution to the development of NAFLD research in the future.

【 授权许可】

CC BY