Histogram parameters derived from T2 weighted images are associated with histopathological findings in rectal cancer - a preliminary study

American Journal of Translational Research

Hans-Jonas Meyer¹  Anne Kathrin Höhn² 

[1] Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig 04103, Germany;Department of Pathology, University of Leipzig, Leipzig 04103, Germany

关键词: Rectal cancer;    MRI;    histogram analysis;    microvessel density;    Ki67;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Histogram analysis can better reflect tumor heterogeneity than conventional imaging analysis. The present study analyzed possible correlations between histogram parameters derived from T2 weighted images and histopathological features in rectal cancer. Seventeen patients with histopathological proven rectal adenocarcinoma were retrospectively acquired with prebioptic 3 T MRI and available histopathological specimens. Histogram analysis was performed using an in-house matlab tool conducting a whole lesion measurement. Histopathology was investigated using Ki67 specimens with calculation of Ki67-index as well as cellularity and nucleic areas and CD31 specimens, with estimation of microvessel density. Several histogram parameters correlated with average nucleic area. Skewness showed a moderate correlation with microvessel density (P = 0.54, P = 0.02). None of the parameters correlated with Ki67-index. Skewness derived from T2 weighted images might be used as a surrogate parameter for average nucleic area and microvessel density. However, none of the parameters were associated with proliferation index.

【 授权许可】

CC BY-NC