P300 latency and amplitude in Alzheimer's disease: a systematic review

Revista Brasileira de Otorrinolaringologia

Pedroso, Renata Valle¹  Fraga, Francisco J.² 

[1] Universidade Estadual Paulista Júlio de Mesquita Filho;Universidade Federal do ABC

关键词: speed of information processing;    processing speed;    information processing;    aged;    older;    elderly;    older people;    alzheimer dementia;    alzheimer disease;    Alzheimer and cross-references of selected articles. RESULTS We found eight studies matching the inclusion criteria. These studies showed that there is a consensus on a P300 latency increase of elderly patients with Alzheimer's disease compared with subjects without the disease. However;    it appears that;    with respect to the P300 amplitude;    there is still no consensus;    however;    it may be related to different methodological variables adopted in the reviewed studies. CONCLUSION There is a need to standardize the variables involved in P300 measurement for senior citizens with Alzheimer's disease in order to be able to compare P300 latency and amplitude values for this population.;   

DOI  :  10.1590/S1808-86942012000400023

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

The P300 plays a key role as a method for monitoring and evaluating dementia, including Alzheimer's disease. OBJECTIVE: The goal of this study was to search for articles which analyzed P300 latency and amplitude values in Alzheimer's disease. METHODS: We searched in the following databases: Web of Science, Pub Med, Psyc Info, Medline, Biological Abstracts and Scielo using the following keywords: speed of information processing, processing speed, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer and cross-references of selected articles. RESULTS: We found eight studies matching the inclusion criteria. These studies showed that there is a consensus on a P300 latency increase of elderly patients with Alzheimer's disease compared with subjects without the disease. However, it appears that, with respect to the P300 amplitude, there is still no consensus; however, it may be related to different methodological variables adopted in the reviewed studies. CONCLUSION: There is a need to standardize the variables involved in P300 measurement for senior citizens with Alzheimer's disease in order to be able to compare P300 latency and amplitude values for this population.

【 授权许可】

CC BY