期刊论文详细信息
Current oncology
Assessing the impact of mailing self-sampling kits for human papillomavirus testing to unscreened non-responder women in Manitoba
F. Jalili1  C. OConaill2  K. Templeton3 
[1] CervixCheck, CancerCare Manitoba;Diagnostic Services, Shared Health Manitoba;University of Manitoba, Research Institute in Oncology and Hematology, CancerCare Manitoba
关键词: Human papillomavirus DNA tests;    Cervical Cancer;    Cancer Screening;   
DOI  :  10.3747/co.26.4575
学科分类:肿瘤学
来源: Multimed, Inc.
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【 摘 要 】

BackgroundCervixCheck, Manitoba’s cervical cancer screening program, conducted a pilot study to assess whether screening participation could be improved in unscreened women by offering a mailed self-sampling kit for human papillomavirus (hpv) testing instead of a Pap test. MethodsIn a prospective cohort study design, a sample of unscreened women ( n= 1052) who had been sent an invitation letter from CervixCheck in the past but who did not respond were randomized to either an intervention group or a control group. The intervention group received a mailed hpv self-sampling kit; the control group received no additional communication. Returned hpv self-sampling swabs were analyzed by a provincial laboratory. After 6 months, screening participation in the two study groups was compared using a logistic regression model adjusted for age and area of residence (urban or rural). Secondary outcomes included hpv positivity, specimen inadequacy, compliance with follow-up, and time to colposcopy. ResultsScreening participation was significantly higher in the intervention group than in the control group ( n= 51, 9.6%, vs.n= 13, 2.5%; odds ratio: 4.7; 95% confidence interval: 2.56 to 8.77). Geographic area of residence (urban or rural) and age were not statistically significant. ConclusionsThe study demonstrated that hpv self-sampling kits can enhance screening participation in unscreened non-responder women in the setting of an organized screening program. Next steps should include additional research to determine the best implementation strategy for hpv self-sampling in Manitoba.

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