Nanogels of acetylated ulvan enhance the solubility of hydrophobic drug curcumin

Bulletin of Materials Science

BUI MINH LY^1¹  LE XUAN HUNG^2²  TRAN THI THANH VAN^1³  TRUONG HAI BANG^1⁴ 

[1] Department of Chemistry, Changwon National, Changwon 51140, Republic of Korea^4;Institute of Chemistry, Vietnam Academy of Science and Technology, Cau Giay Hanoi 10072, Vietnam^3;Institute of Research and Development, Duy Tan University, Da Nang 50000, Vietnam^2;Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 57000, Vietnam^1

关键词: Nanogel;    ulvan;    curcumin;    green seaweed.;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

Curcumin (Cur) is a polyphenol showing various bioactivities including anti-tumour activity. However, poor solubility of Cur in aqueous solution is a major barrier to its bioavailability and clinical efficacy. In this study, hydrophobicallymodified ulvan was considered to self-assemble to fabricate nanogels. This is a network of hydrophilic segments with hydrophobic microdomains in the nanopores, which keeps Cur from dispersing into the media and raise Cur solubility in water by 20,000 times. A Cur-loaded acetylated ulvan nanogel was characterized by scanning electron microscopy, transmission electron microscopy and dynamic light scattering. This result confirmed that hydrophobically modified ulvan could be used as a self-organizing assembly nanogel to carry and deliver water-insoluble bioactive compounds.

【 授权许可】

CC BY