Multiparametric MRI - local staging of prostate cancer and beyond

Radiology and Oncology

Iztok Caglic^1,2³  Viljem Kovac^2,3⁴  Tristan Barrett^4,5⁵ 

[1] CamPARI Clinic, Addenbrooke’s Hospital and University of Cambridge, Cambridge, UK^5;Department of Radiology, Addenbrooke’s Hospital and University of Cambridge, Cambridge, UK^4;Department of Radiology, Norfolk and Norwich University Hospital, Norwich, UK^1;Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia^2;Institute of Oncology Ljubljana, Ljubljana, Slovenia^3

关键词: multiparametric MRI;    prostate cancer;    staging;   

DOI  :  10.2478/raon-2019-0021

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundAccurate local staging is critical for treatment planning and prognosis in patients with prostate cancer (PCa). The primary aim is to differentiate between organ-confined and locally advanced disease with the latter carrying a worse clinical prognosis. Multiparametric MRI (mpMRI) is the imaging modality of choice for the local staging of PCa and has an incremental value in assessing pelvic nodal disease and bone involvement. It has shown superior performance compared to traditional staging based on clinical nomograms, and provides additional information on the site and extent of disease. MRI has a high specificity for diagnosing extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node (LN) metastases, however, sensitivity remains poor. As a result, extended pelvic LN dissection remains the gold standard for assessing pelvic nodal involvement, and there has been recent progress in developing advanced imaging techniques for more distal staging.

【 授权许可】

Unknown