Versatile and Automated 3D Polydimethylsiloxane (PDMS) Patterning for Large-Scale Fabrication of Organ-on-Chip (OOC) Components

Proceedings

Dekker, Ronald¹  Kersjes, Sebastiaan²  Solano, William Quiros³  Gaio, Nikolas⁴  Sarro, Pasqualina⁵ 

[1] Author to whom correspondence should be addressed.;BIOND Solutions B.V., Mekelweg 4, 2628 CD Delft, The Netherlands;Besi Netherlands B.V., 6921 RW Duiven, The Netherlands;Laboratory of Electronic Components, Technology & Materials (ECTM), EKL, Delft University of Technology, Feldmannweg 17, 2628 CT Delft, The Netherlands;Philips Research, 5656 AE Eindhoven, The Netherlands

关键词: 3D;    PDMS;    molding;    organ-on-chip;   

DOI  :  10.3390/proceedings2130873

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

We present a reproducible process to directly pattern 3-Dimensional (3D) polydimethylsiloxane (PDMS) structures for Organ-on-Chips (OOC) via automated molding. The presented process employs a commercially available system from IC packaging improving the fabrication process for microfluidic channels and thin membranes, which are components frequently used in OOCs. The process removes the manual steps used previously in the fabrication of microfluidic channels and improves the control over the thickness of the PDMS layers. The process was also employed to fabricate and pattern thin PDMS membranes on silicon wafers, without the use of lithography and etching steps and in combination with 3D structures. The use of foil assisted molding techniques presented in this work is an important step toward the large-scale manufacturing of OOCs.

【 授权许可】

CC BY