Organ transplantation and gut microbiota: current reviews and future challenges

American Journal of Translational Research

Zhao Peng¹  Xing Chen²  Jie Xiao³  Hui Sun⁴  Yuxiao Liao⁵  Weiqiang Chen⁶  Zhanjie Wei⁷ 

[1] Department of Cardio-Thoracic Surgery, Ganzhou Peoples Hospital, Ganzhou 341000, Jiangxi, China;Department of Cardiovascular Surgery, Central Hospital of Wuhan, Wuhan 430022, Hubei, China;Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China;Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China;Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China;Department of Thyroid Surgery, Central Hospital of Wuhan, Wuhan 430022, Hubei, China;Department of Traumatology, BG Trauma Center, University of Tbingen, Schnarrenbergstr. 95, Tbingen 72076, Germany

关键词: Organ transplantation;    gut microbiota;    complication;    prognosis;    fecal microbiota transplantation;    probiotic;    prebiotic;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Organ transplantation is often the only effective treatment for patients with end-stage diseases, such as heart, liver, kidney and small bowel failure and is carried out frequently worldwide. Still the post-transplantation complications remain health- and life-threatening outcome that needed to be resolved. With the rapid development of molecular technologies in recent years, more and more researchers realize that the gut microbiota may play a critical role in human diseases. The intestinal microbiome has been proved to provide a lot of functions to the host, such as digesting food, modulating metabolism, promoting angiogenesis and regulating the immune system. Several studies have investigated the alteration of intestinal microbiota in post-transplantation patients and observed significant changes in the intestinal microbiome compared to the pre-transplant condition. Due to the abovementioned features that the gut microbiota may be used in the prognosis of clinical outcome of organ transplantation. In addition, the FMT (fecal microbiota transplantation), probiotics and prebiotics as the newest therapy methods, effectiveness of which has been verified in some diseases, such as Clostridium difficile infection, inflammatory bowel disease and other chronic disorders, might be used as the prognosis tool in organ transplantation as well. The purpose of this present review is to elucidate the relationship between gut microbiota and organ transplantation as well as the potential use of new therapies like fecal microbiota transplantation, probiotic and prebiotic administration after the transplantation, and provide some ideas for future researches in field of organ transplantation.

【 授权许可】

CC BY-NC