Old Drawback on Azlactone Formation Revealed by a Combination of Theoretical and Experimental Studies

Journal of the Brazilian Chemical Society

Castro, Pedro P. de¹ 

[1] Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil

关键词: azlactone;    oxazolone;    DFT.;   

DOI  :  10.21577/0103-5053.20180155

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

New insights into the formation of azlactone heterocycles bearing different substituents are hereby presented. The sum of both kinetic and thermodynamic factors contributes for the formation of 2-alkyl or 2-aryl substituted azlactones, while the cyclization of 2-alcoxy azlactones is less favored. These results are in perfect accordance with experimental observations obtained by infrared (IR) and electrospray ionization mass spectrometry (ESI(+)-MS) of the crude reaction mixture.

【 授权许可】

CC BY