High-throughput flow injection analysis-MRM3 (FIA-MRM3) spectrometry for alternative fast screening of the isomeric methamphetamine and phentermine in blood for forensic toxicology cases in Malaysia

Toxicology Research and Application

Fathiah AZubaidi¹ 

关键词: MRM3;    FIA (flow injection analysis);    high-throughput screening;    isomeric compounds;    methamphetamine;    phentermine;    WBS;    DBS;   

DOI  :  10.1177/2397847319831368

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Methamphetamine (MA) and phentermine (PTM) are critical isomeric compounds that often coexist in biological specimen in toxicology cases which have similar nominal mass. The dependency of high-resolution mass spectrometer and special chiral stationary phase column for separation of isomeric compound impedes screening throughput especially in meeting high sampling demand.

【 授权许可】

CC BY