Persistence of the otoprotective effect: how long does otoprotection against amikacin lasts?

Revista Brasileira de Otorrinolaringologia

Oliveira, Andreia Ardevino de¹  Campos, Matheus de Souza² 

[1] USP;USP, Ribeirão Preto

关键词: amikacin;    aminoglycosides;    drug toxicity;    hair cells;    auditory;    inner;    hair cells;    auditory;    outer.;   

DOI  :  10.5935/1808-8694.20120032

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

There is evidence that a "resistance phenomenon" occurs when a none-damaging dose of amikacin protects the hair cells from ototoxicity. Our goal is to prove that this resistance is persistent. METHOD: Experimental study - 14 albino guinea pigs (Cavia porcellus) divided into three groups. The auditory function was assessed by distortion product otoacoustic emissions (DPOAE): before exposure to amikacin, on the 15th day after the non-damaging dose was injected, at the end of the damage dose injection and prior to decapitation. RESULTS: Group A (control) presented normal hearing and histological pattern. Group B (amikacin 20mg/kg/day (IM) for 30 days and affecting dose (400 mg / kg / day) for 12 days and Group C (same protocol of Group B, but kept for 60 days and slaughtered), the DPOAE confirmed normal auditory function in the pre-exposure and maintenance of the standard-dose; however, significant loss of auditory function after the end of the damaging dose injection. CONCLUSION: The protection phenomenon did not extended for a period of 30 to 60 days after the application of damaging doses of amykacin.

【 授权许可】

CC BY