Gene fusion of heterophyletic gamma-globin genes in platyrrhine primates

Journal of genetics

JOSÉ IGNACIO ARROYO^1,2,3²  MARIANA F. NERY^4⁴ 

[1] Center for Climate and Resilience Research (CR)2, Santiago 8370449, Chile^3;Departamento de Ecología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile^1;Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas 13148-252, Brazil^4;Instituto de Ecología y Biodiversidad (IEB), Santiago 7800003, Chile^2

关键词: gene duplication;    gene fusion;    gene conversion;    recombination;    globins;    primates.;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

We performed phylogenetic analyses of HBG genes to assess its origin and interspecific variation among primates. Our analyses showed variation in HBG genes copy number ranging from one to three, some of them pseudogenes. For platyrrhines HBG genes, phylogenetic reconstructions of flanking regions recovered orthologous clades with distinct topologies for 5' and 3' flanking regions. The 5' region originated in the common ancestor of platyrrhines but the 3' region had an anthropoid origin. We hypothesize that the platyrrhine HBG genes of 5' and 3' heterophyletic origins arose from subsequent fusions of the (earlier) platyrrhine 5' portion and the (later) anthropoid 3' portion.

【 授权许可】

CC BY