Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YPOS mice

The Journal of Veterinary Medical Science

Yuuka MIURA¹  Toshifumi YOKOYAMA²  Chinatsu HASEGAWA³  Anzu YAMAMOTO⁴ 

[1] Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan;Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan;Departments of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan;Division of Drug and Structural Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

关键词: C57BL/6;    Mus musculus poschiavinus;    sex reversal;    substrain;    testis differentiation;   

DOI  :  10.1292/jvms.18-0621

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

C57BL/6J-XYPOS (B6J-XYPOS) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XYPOS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XYPOS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.

【 授权许可】

Unknown