A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model

BMB Reports

Min Bum Lee^1¹  Jong-Hwa Jang^2²  Hyuk Soon Kim^1³ 

[1] College of Pharmacy, Duksung Women’s University, Seoul 01369, Korea^3;Department of Dental Hygiene, Hanseo University, Seosan 31962^2;Department of Immunology, School of medicine, Konkuk University, Chungju 27478^1

关键词: Contact hypersensitivity;   

DOI  :  

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells.

【 授权许可】

Unknown