Calmodulin Antagonists as Potential Therapeutic Agents for Cancer Treatment “Breast Cancer”

Proceedings

Kumar, Vijay¹  Tani, Ahmad Zaidi²  Salih, Falah A. M.³  Hadi, Janan⁴ 

[1] Author to whom correspondence should be addressed.;Biotechnology Research Institute, University Malaysia, Kota kinabalu 88400, Sabah, Malaysia;Department of Biomedical and Therapeutic, Faculty of Medicine, University Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia;Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018

关键词: calmodulin antagonist;    breast cancer treatment;   

DOI  :  10.3390/proceedings2251550

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Although cancer research undergone a rapid expansion, there is no potential cure and the disease remains one of the leading causes of mortality worldwide. Breast cancer continues as the female malignancy and a major cause of death in middle-aged women. Calmodulin can interact with large number of different target proteins and modulate their activity in different ways. Calmodulin antagonists have been reported to induce apoptosis and inhibit tumor cell growth. However, the potential effects of these target agents on various cancer within the molecular levels are poorly understood. The main objective of this study is to evaluate the potency of a number of calmodulin antagonists on the growth of human breast cancer cell lines. In addition, preliminary trials were carried out to find the role of these agents within the molecular levels. The finding indicates that Calmodulin antagonists might be the key for future breast cancer treatment strategy.

【 授权许可】

CC BY