Localization patterns of cathepsins K and X and their predictive value in glioblastoma

Radiology and Oncology

Tamara T. Lah^1,2¹  Cornelis J.F. Van Noorden^1,9²  Barbara Breznik^1,2³  Andrej Porcnik^5⁴  Miha Koprivnikar Krajnc^1⁵  Roman Bosnjak^5⁶  Janko Kos^7,8⁷  Andrej Blejec^6⁸  Clara Limback^3,4⁹ 

[1] Amsterdam UMC, Cancer Center Amsterdam, Department of Medical Biology at the Academic Medical Center, Amsterdam, The Netherlands^9;Department of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia^8;Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia^1;Department of Histopathology, Charing Cross Hospital, Fulham Palace Road, London, UK^3;Department of Neurosurgery, University Clinical Centre Ljubljana, Ljubljana, Slovenia^5;Department of Organisms and Ecosystems Research, National Institute of Biology, Ljubljana, Slovenia^6;Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia^7;Faculty of Medicine, Imperial College London, South Kensington Campus, London, UK^4;Internationaml Postgraduate School Jozef Stefan, Ljubljana, Slovenia^2

关键词: cathepsins;    glioblastoma;    immunohistochemistry;    patient survival;    cancer stem cell niches;   

DOI  :  10.2478/raon-2018-0040

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundGlioblastoma is a highly aggressive central nervous system neoplasm characterized by extensive infiltration of malignant cells into brain parenchyma, thus preventing complete tumor eradication. Cysteine cathepsins B, S, L and K are involved in cancer progression and are overexpressed in glioblastoma. We report here for the first time that cathepsin X mRNA and protein are also abundantly present in malignant glioma.

【 授权许可】

Unknown