Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population

BMB Reports

Hyo-Jeong Ban^3¹  Hyung-Cheol Kim^4²  Jung-Won Park^1,6³  Bok-Ghee Han^5⁴  Soo-Jong Hong^1,7⁵  Young Jin Kim^4⁶  Eun-Jin Kim^1,2⁷  Dankyu Yoon^1,2⁸ 

[1] Allergy TF, Department of Immunology and Pathology, Korea National Institute of Health^2;Center for Genome Science, Korea National Institute of Health, Osong 363-951^5;Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736^7;Department of Internal Medicine and Institute of Allergy, Yonsei University College of Medicine, Seoul 120-752^6;Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea^8;Division of Bio-Medical Informatics, Center for Genome Science, Korea National Institute of Health^3;Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health^4;Research Center for Standardization of Allergic Disease^1

关键词: Allergic diseases;   

DOI  :  

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.

【 授权许可】

Unknown