Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside

Cellular Physiology and Biochemistry

Yaxing Zhang¹ 

关键词: Hydrogen;    Vascular disease;    Heart disease;    Metabolic disease;   

DOI  :  10.1159/000489737

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Hydrogen (H2) is colorless, odorless, and the lightest of gas molecules. Studies in the past ten years have indicated that H2 is extremely important in regulating the homeostasis of the cardiovascular system and metabolic activity. Delivery of H2 by various strategies improves cardiometabolic diseases, including atherosclerosis, vascular injury, ischemic or hypertrophic ventricular remodeling, intermittent hypoxia- or heart transplantation-induced heart injury, obesity and diabetes in animal models or in clinical trials. The purpose of this review is to summarize the physical and chemical properties of H2, and then, the functions of H2 with an emphasis on the therapeutic potential and molecular mechanisms involved in the diseases above. We hope this review will provide the future outlook of H2-based therapies for cardiometabolic disease.

【 授权许可】

CC BY-NC-ND