Revisión sistemática: estrategias virales para la inducción de cáncer “virus de Epstein-Barr: latencia y mecanismos asociados a la oncogénesis viral”

Universidad Industrial de Santander. Revista. Salud

Plata S, Laura M¹ 

[1] Universidad Industrial de Santander, Colombia

关键词: Epstein-Barr virus;    oncogenes;    viral proteins;    latency;    gene expression;    herpesvirus.;   

DOI  :  10.18273/revsal.v50n3-2018010

学科分类：医学（综合）

来源: Universidad Industrial de Santander

【 摘 要 】

Chronic infection with oncogenic viruses is responsible for approximately 20% of all cancers worldwide in humans, this viral transformation represents a complex, multistage and multifactorial process. An example is the Epstein-Barr virus (EBV), a herpesvirus that latently infects over 90% of the population. Although the infection often courses asymptomatically, EBV is able to modify its genomic expression by establishing different latency phases, thus altering the B lymphocytes and epithelial cells metabolism, a determinant process in the appearance and development of different pathologies ranging from infectious mononucleosis to oncological processes such as Burkitt’s lymphoma, gastric cancer and nasopharyngeal cancer.

【 授权许可】

Unknown