HER2 and TOP2A Gene Amplification and Protein Expression in Upper Tract Urothelial Carcinomas

Pathology oncology research: POR

Klaus Aumayr¹ 

[1] Medical University of Vienna

关键词: HER2;    TOP2A;    Polysomy 17;    Amplification;    Anthracyclines;    Urothelial carcinoma;   

DOI  :  10.1007/s12253-017-0260-0

学科分类：生理学与病理学

来源: Springer

【 摘 要 】

IntroductionHER2 expression is associated of features of advance disease and poor prognosis in various malignancies [1]. Targeting HER2 with monoclonal antibodies has resulted in significant reduction of tumor recurrence and death in breast cancer [2, 3, 4, 5]. In urothelial carcinomas HER2 is expressed in approximately 5–15% of tumors [6] and seems to predict worse pathology and outcomes when overexpressed in bladder cancer histologic specimen [7] as well as circulating tumor cells in peripheral blood [8].

【 授权许可】

CC BY