Lamotrigine ethanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications

Hall, C.L.¹ 

[1] School of Chemistry, University of Bristol, Cantock's Close, Bristol, England BS8 1TS, England

关键词: CRYSTAL STRUCTURE;    LAMOTRIGINE;    ETHANOLATE;   

DOI  :  10.1107/S2056989018005819

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethano­late solvate, C9H7Cl2N5·C2H5OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine mol­ecules form dimers through N—H⋯N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol mol­ecule exhibiting disorder with an occupancy ratio of 0.516 (14):0.484 (14).

【 授权许可】

CC BY