Triadimefon Disrupts Working Memory in the Matching-to-Position Task

SAGE Open

John M.Holden¹ 

关键词: triadimefon;    psychostimulant;    cocaine;    amphetamine;    working memory;    matching-to-position;    retinoic acid;   

DOI  :  10.1177/2158244018805798

学科分类：社会科学、人文和艺术（综合）

来源: Sage Journals

【 摘 要 】

Triadimefon (TDF) is a fungicide which has psychostimulant properties similar to cocaine and amphetamine. Past studies with psychostimulants suggests that acute exposure leads to disruptions in working memory. In this study, we examined the effects of TDF exposure (relative to corn oil control) on performance in the delayed matching-to-position task in two separate studies using Sprague-Dawley male rats. In both studies, TDF exposure led to significantly poorer performance across delays. TDF shows similar properties to cocaine and amphetamine in terms of disrupting working memory.

【 授权许可】

CC BY