What do eye movements tell us about patients with neurological disorders? — An introduction to saccade recording in the clinical setting —

Proceedings of the Japan Academy, Series B. Physical and Biological Sciences

Yasuo TERAO¹  Hideki FUKUDA²  Okihide HIKOSAKA³ 

[1] Department of Cell Physiology, Kyorin University;Neurological Clinic for Children;Section of Neuronal Networks, Laboratory of Sensorimotor Research, National Eye Institute

关键词: ataxia;    basal ganglia;    cerebellum;    cerebral cortex;    parkinsonism;    saccade;   

DOI  :  10.2183/pjab.93.049

学科分类：物理（综合）

来源: Japan Academy

【 摘 要 】

Non-invasive and readily implemented in the clinical setting, eye movement studies have been conducted extensively not only in healthy human subjects but also in patients with neurological disorders. The purpose of saccade studies is to “read out” the pathophysiology underlying neurological disorders from the saccade records, referring to known primate physiology. In the current review, we provide an overview of studies in which we attempted to elucidate the patterns of saccade abnormalities in over 250 patients with neurological disorders, including cerebellar ataxia and brainstem pathology due to neurodegenerative disorders, and what they tell about the pathophysiology of patients with neurological disorders. We also discuss how interventions, such as deep brain stimulation, affect saccade performance and provide further insights into the workings of the oculomotor system in humans. Finally, we argue that it is important to understand the functional significance and behavioral correlate of saccade abnormalities in daily life, which could require eye tracking methodologies to be performed in settings similar to daily life.

【 授权许可】

Unknown