Estrogen receptor β stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells

BMB Reports

Yoongho Lim^2¹  Il-Yeup Jeong^1²  Ji-Ha Kim^1³  Young Han Lee^3,4⁴ 

[1] Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science^3;Division of Bioscience and Biotechnology, BMIC^2;Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan 426-791^1;Research Center for Transcription Control, Konkuk University, Seoul 143-701, Korea^4

关键词: C6 glioma;   

DOI  :  

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

The Egr-1 is an immediate early response gene encoding a transcription factor that functions in the regulation of cell growth, differentiation, and apoptosis. Estrogen has diverse physiological effects, including cellular proliferation and neuroprotection against brain injury. There are two types of estrogen receptors (ERs), ERα and ERβ. ERα-induced Egr-1 expression has been extensively studied; however, the role of ERβ is yet not known. In the present study, we investigated whether or not ERβ induces Egr-1 expression in C6 rat glioma cells, which express ERβ but not ERα. Our results show that ERβ promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade.

【 授权许可】

Unknown