Imaging Fluorophore-Labelled Intestinal Tissue via Fluorescence Endoscope Capsule

Proceedings

Al-Rawahani, Mohammed¹  Turcanu, Mihnea²  Beeley, James³  Melino, Gianluca⁴ 

[1] Author to whom correspondence should be addressed.;Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018;School of Engineering, University of Glasgow, Glasgow, Scotland G12 8LT, UK;School of Science and Engineering, University of Dundee, Scotland DD1 4HN, UK

关键词: capsule endoscopy;    fluorescence imaging;    fluorescence labelling;    tissue fluorescence;   

DOI  :  10.3390/proceedings2130766

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue autofluorescence between healthy and diseased areas in response to illumination, or application of fluorescent labels which preferentially bind to diseased sites. To validate the capsule’s capability to image fluorescently-labelled tissue, a small area of a sample of ex vivo porcine small intestine was sonicated with 6 nm CdZnMg fluorescent quantum dots, and the labelled area clearly differentiated from surrounding tissue by the fluorescence imaging capsule.

【 授权许可】

CC BY