Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

BMC Microbiology

Henry M Kariithi¹  Sorge Kelm²  Fathiya M Khamis³  Linda De Vooght⁴  ikbal Agah iNCE⁵  Guler Demirba-Uzel⁶  Irene K Meki⁷  Just M Vlak⁸  Anne Geiger⁹  Flobert Njiokou^1,10  Daniela I Schneider^1,11  Florence N Wamwiri^1,12 

[1] Biotechnology Research Institute, Kenya Agricultural & Livestock Research Organization, Nairobi, Kenya;Centre for Biomolecular Interactions Bremen, Faculty for Biology & Chemistry, Universitt Bremen, Bremen, Germany;Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium;Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, USA;Department of Medical Microbiology, Acbadem Mehmet Ali Aydnlar University, School of Medicine, Istanbul, Turkey;INTERTRYP, Institut de Recherche pour le Dveloppement, University of Montpellier, Montpellier, France;Insect Pest Control Laboratory, FAO/IAEA Agriculture & Biotechnology Laboratory, IAEA Laboratories Seibersdorf, Seibersdorf, Austria;Institute of Chemical, Environmental & Biological Engineering, Research Area Biochemical Technology, Vienna University of Technology, Vienna, Austria;International Centre of Insect Physiology and Ecology, Nairobi, Kenya;Laboratory of Parasitology and Ecology, Faculty of Sciences, Department of Animal Biology and Physiology, University of Yaound 1, Yaound, Cameroon;Laboratory of Virology, Wageningen University and Research, Wageningen, The Netherlands;Trypanosomiasis Research Centre, Kenya Agricultural & Livestock Research Organization, Kikuyu, Kenya

关键词: Glossina;    Microbiota;    Paratransgenesis;    Vector competence;    Trypanosoma-refractoriness, sterile insect technique;    Hytrosaviridae;   

DOI  :  10.1186/s12866-018-1280-y

学科分类：微生物学和免疫学

来源: BioMed Central

【 摘 要 】

With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013–2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP’s major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

【 授权许可】

CC BY