Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan

Endocrine journal

Seiji Fukumoto¹  Satoshi Kusuda²  Sachiko Kitanaka³  Satomi Koyama⁴  Yukihiro Hasegawa⁵  Takuo Kubota⁶  Kenji Ihara⁷  Taichi Kitaoka⁸  Ikuma Fujiwara⁹  Yosikazu Nakamura^1,10  Hirofumi Nakayama^1,11 

[1] Department of Pediatric Endocrinology and Environmental Medicine, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan;Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Aichi 467-8602, Japan;Department of Pediatrics, Dokkyo Medical University, Tochigi 321-0293, Japan;Department of Pediatrics, Kyorin University, Tokyo 181-0004, Japan;Department of Pediatrics, Oita University Faculty of Medicine, Oita 879-5593, Japan;Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan;Department of Pediatrics, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan;Department of Public Health, Jichi Medical University, Tochigi 329-0498, Japan;Division of Endocrinology and Metabolism, Tokyo Metropolitan Children’s Medical Center, Tokyo 183-8561, Japan;Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima 770-8503, Japan;Study group of Survey and Estimation of Incidence Rate of Childhood Symptomatic Vitamin D

关键词: Vitamin D deficiency;    Rickets;    Hypocalcemia;    Children;    Nationwide survey;   

DOI  :  10.1507/endocrj.EJ18-0008

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145–222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9–1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7–4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies.

【 授权许可】

Unknown