Real-world patient- and caregiver-reported outcomes in advanced breast cancer

Current oncology

M. Mates²  T. Tran³  F. Couture⁴  J. Lachaine⁶  J. Lemieux⁸  C. Prady⁹  P. Chabot^1,10  G. Zanotti^1,11  V. Lambert-Obry^1,12  A. Castonguay^1,13  A. Gouault-Laliberté^1,14 

[1] Centre hospitalier affilié Universitaire de Lévis;Queens University;Cancer Centre of Southeastern Ontario;Centre intégré de santé et de services sociaux de la Montérégie-Centre;Greenfield Park;affilié à l’Université deSherbrooke;Centre de santé et de services sociaux Alphonse-Desjardins;Centre hospitalier universitaire de Québec;Centre intégré de cancérologie de la Montérégie;Hôpital Maisonneuve-Rosemont;Kingston General Hospital;PeriPharm Inc.;Pfizer Canada;Pfizer Inc.

关键词: Real-world evidence;    advanced breast cancer;    patient-reported outcomes;    caregivers;    quality of life;    utility;    productivity losses;    health care resource utilization;   

DOI  :  10.3747/co.25.3765

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

BackgroundAdvanced breast cancer (abc) represents a substantial burden for patients and caregivers. In the present study, we aimed to estimate quality of life (qol), utility, productivity loss, pain, health care resource utilization, and costs for patients with abc, and qol, utility, and productivity loss for their caregivers. MethodsThis multicentre prospective non-interventional study was conducted in Canada. Eligible participants were postmenopausal women with estrogen receptor–positive, her2-negative unresectable abc and their caregivers. Validated questionnaires were used to measure qol, utility, productivity loss, and pain. Patients and caregivers were classified into 4 health states typically used in oncology economic modelling: first-line progression-free (1l-pf), firstline progressive disease (1l-pd), second- or subsequent-line progression-free (≥2l-pf), and second- or subsequent-line progressive disease (≥2l-pd). ResultsMost patients and caregivers accepted to participate, with total recruitment of 202 patients and 78 caregivers. Compared with patients in pf, patients in pd had lower mean qol scores (52.9 ± 29.9 for 1l-pd vs. 68.2 ± 23.2 for 1l-pf, and 54.0 ± 23.6 for ≥2l-pd vs. 66.0 ± 22.1 for ≥2l-pf), lower mean utility values (0.64 ± 0.22 for 1l-pd vs. 0.73 ± 0.20 for 1l-pf, and 0.65 ± 0.25 for ≥2l-pd vs. 0.74 ± 0.18 for ≥2l-pf), and greater productivity loss (39.4 ± 27.7 for 1l-pd vs. 27.5 ± 30.1 for 1l-pf, and 37.6 ± 29.2 for ≥2l-pd vs. 32.0 ± 29.0 for ≥2l-pf). Compared with caregivers of patients in pf, caregivers of patients in pd had lower qol scores and utility values, and greater productivity loss. ConclusionsStudy results indicate that, for patients and caregivers, pd health states are associated with a deterioration of qol and utility and a decrease in productivity in both 1l and ≥2l.

【 授权许可】

Unknown