Stathmin 1 in normal and malignant hematopoiesis

BMB Reports

Sara Teresinha Olalla Saad^1¹  Jo?o Agostinho Machado-Neto^1² 

[1] Department of Internal Medicine, University of S?o Paulo at Ribeir?o Preto Medical School, Ribeir?o Preto, S?o Paulo, Brazil^2;Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ci?ncia e Tecnologia do Sangue, Campinas, S?o Paulo, Brazil^1

关键词: Hematopoiesis;   

DOI  :  

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines. However, during the differentiation of primary hematopoietic cells, Stathmin 1 expression decreases in parallel to decreases in the proliferative potential of early hematopoietic progenitors. The scope of the present review is to survey the current knowledge and highlight future perspectives for Stathmin 1 in normal and malignant hematopoiesis, with regard to the expression, function and clinical implications of this protein.

【 授权许可】

Unknown