New Approach to Detect Coiled Coil and Leucine Zipper Motifs in Protein Sequences

Journal of computational biology: A journal of computational molecular cell biology

DinkoOsmankovic^1,2¹  SemirDoric^3²  LadaLukic Bilela^4³  NarisPojskic^3⁴ 

[1] Address correspondence to: Dr. Dinko Osmankovic, Department of Automatic Control and Electronics, Faculty of Electrical Engineering, University of Sarajevo, Zmaja od Bosne 8, Sarajevo 71000, Bosnia and Herzegovina^1;Department of Automatic Control and Electronics, Faculty of Electrical Engineering, University of Sarajevo, Sarajevo, Bosnia and Herzegovina^2;Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina^4;Laboratory for Bioinformatics and Biostatistics, Institute for Genetic Engineering and Biotechnology, University of Sarajevo, Sarajevo, Bosnia and Herzegovina^3

关键词: coiled coil;    K means clustering;    leucine zipper;    protein scale.;   

DOI  :  10.1089/cmb.2018.0104

学科分类：生物科学（综合）

来源: Mary Ann Liebert, Inc. Publishers

【 摘 要 】

This article presents a new approach to detect coiled coil and leucine zipper (L-Zip) motifs in protein sequences. The approach is based on protein scale calculation and sequence analysis. For this purpose, the wavelet-based local extrema extraction is employed, and window-based variations of local extrema afterward. This, in turn, provided a way to distinguish coiled coil subsequences and potential L-Zip motifs. The approach is validated on carefully chosen protein sequences that return inconclusive results within known frameworks for L-Zip detection, for example, 2ZIP. The results show that this new approach represents an improvement over previously presented approaches.

【 授权许可】

Unknown