FOXA1 transcriptionally up-regulates cyclin B1 expression to enhance chondrosarcoma progression

American Journal of Cancer Research

Yu-Chia Liu¹  Chiao-Chen Chung²  Yung-Luen Yu³  Tsung-Ming Chen⁴  Zong-Shin Lin⁵ 

[1] Cancer Biology and Drug Discovery Ph.D. Program, China Medical University, Taichung 40447, Taiwan;Center for Molecular Medicine, China Medical University Hospital, Taichung 40447, Taiwan;Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan;Department of Biotechnology, Asia University, Taichung 413, Taiwan;Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 40402, Taiwan

关键词: Chondrosarcoma;    FOXA1;    cell cycle;    G2/M phase;    cyclin B1;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Chondrosarcoma is a malignant and common bone tumor that is highly resistant to radiation and chemotherapy. At this moment, amputation surgery is the only option which unfortunately has serious impact to daily lives of the patients. Thus, there is an urgent need to understand causative molecular mechanisms underlying the disease for more accurate prognosis and more effective targeted treatment. In the current study, we identify the transcription factor FOXA1 through cDNA microarray screening comparing normal versus chondrosarcoma cells and investigate the mechanisms underlying its function in chondrosarcoma development. We show that FOXA1 enhances expression of the cyclin B1 gene, which in turn drives cell cycle progression through G2-M transition thus promotes cell cycle progression of chondrosarcoma cells.

【 授权许可】

CC BY-NC