Kn-Ba: a novel serine protease isolated from Bitis arietans snake venom with fibrinogenolytic and kinin-releasing activities

Journal of Venomous Animals and Toxins including Tropical Diseases

Ângela Alice Amadeu Megale¹ 

[1]Butantan Institute

关键词: Bitis arietans;    Venom;    Antivenom;    Serine protease;    Fibrinogenolytic;    Kinin-releasing activity;   

DOI  :  10.1186/s40409-018-0176-5

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

BackgroundBitis arietans is a venomous snake found in sub-Saharan Africa and in parts of Morocco and Saudi Arabia. The envenomation is characterized by local and systemic reactions including pain, blistering, edema and tissue damage, besides hemostatic and cardiovascular disturbances, which can cause death or permanent disabilities in its victims. However, the action mechanisms that provoke these effects remain poorly understood, especially the activities of purified venom components. Therefore, in order to elucidate the molecular mechanisms that make the Bitis arietans venom so potent and harmful to human beings, this study reports the isolation and biochemical characterization of a snake venom serine protease (SVSP).

【 授权许可】

CC BY