Serum autotaxin levels are associated with Graves’ disease

Endocrine journal

Masako Nishikawa¹  Makoto Kurano²  Osamu Araki³  Kazuki Nakawatari⁴  Takahiro Nojiri⁵  Satoshi Shimamoto⁶ 

[1] Bioscience Division, TOSOH Corporation, Kanagawa, Japan;Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan;Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan;Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan;Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan

关键词: Graves’ disease;    Autotaxin;    Anti-thyroid drugs;    Lysophosphatidic acids;    Thyroid hormones;   

DOI  :  10.1507/endocrj.EJ18-0451

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Graves’ Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the ATX/LPA axis in some immunological disturbances has been proposed. In this study, we investigated the association between serum ATX levels and Graves’ disease. We measured the levels of serum total ATX and ATX isoforms (classical ATX and novel ATX) in patients with untreated Graves’ disease, Graves’ disease treated with anti-thyroid drugs, patients with subacute thyroiditis, silent thyroiditis, Plummer’s disease, or Hashimoto’s thyroiditis, and patients who had undergone a total thyroidectomy, as well as normal subjects. The serum total ATX and ATX isoform levels were higher in the patients with Graves’ disease, compared with the levels in the healthy subjects and the patients with subacute thyroiditis. Treatment with anti-thyroid drugs significantly decreased the serum ATX levels. The serum ATX levels and the changes in serum ATX levels during treatment were moderately or strongly correlated with the serum concentrations or the changes in thyroid hormones. However, the administration of T3 or T4 did not increase the expression or serum levels of ATX in 3T3L1 adipocytes or wild-type mice. In conclusion, the serum ATX levels were higher in subjects with Graves’ disease, possibly because of a mechanism that does not involve hyperthyroidism. These results suggest the possible involvement of the ATX/LPA axis in the pathogenesis of Graves’ disease.

【 授权许可】

Unknown